The growing importance of Mouth disintegrating tablet was underlined recently when European Pharmacopoeia adopted the terms “Orodispersible Tablet” as a tablet that to be placed in the mouth where it disperses rapidly before swallowing. Their characteristic advantages such as administration without water anywhere, anytime lead to their suitability to geriatric and pediatric patients. In case of Orodispersible tablet however, main problem is bitter taste of the drug due to dispersion of active component in the saliva. Hence, it is necessary to mask the bitter taste of drug before formulation of orodispersible tablets. The aim of this study was to prepare Orodispersible tablet of taste-masked granules of Ondansetron HCl, which is bitter in taste. The taste-masked granules were prepared using Eudragit E100 by dispersion coating. The loading process was further optimized for the drug Eudragit E100 ratio. The taste-masked complex was evaluated for taste, in vitro release study. Orodispersible tablets of taste-masked complex were prepared using various superdisintegrants in different concentrations by direct compression method. All the formulations were evaluated for the influence of disintegrants and their concentration on the disintegration time of Orodispersible tablet. Tablet containing Indion 414 (Weak Cation Exchange Resin) showed better disintegrating character with rapid release at low concentration (More than 90% of drug released in 15 min.) Hence Eudragit E100 shows good taste masking effect.
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